Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles-Reference-Cited by-同舟云学术

Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles

Published:2015-02 Issue:3 Volume:10 Page:419-431
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Xu Yingying¹,Tang Huan¹,Wang Haifang²,Liu Yuanfang¹²

Affiliation:

1. Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, China

2. Institute of Nanochemistry & Nanobiology, Shanghai University, Shanghai, China

Abstract

Aim: The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice. Materials & methods: Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed. Results: Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP. Conclusion: Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm.14.111

Reference32 articles.

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