Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach-Reference-Cited by-同舟云学术

Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach

Published:2019-06 Issue:8 Volume:11 Page:951-968
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Mohandas Namitha¹²,Loke Yuk Jing¹,Hopkins Stephanie¹³,Mackenzie Lisa⁴,Bennett Carmen⁴,Berkovic Samuel F⁵,Vadlamudi Lata⁴⁶,Craig Jeffrey M¹²⁷

Affiliation:

1. Environmental & Genetic Epidemiology Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia

2. Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Victoria, Australia

3. School of Medicine & Public Health, University of Newcastle, Newcastle, New South Wales, Australia

4. Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Queensland, Australia

5. Epilepsy Research Centre, University of Melbourne, Austin Health, Victoria, Australia

6. Royal Brisbane & Women's Hospital, Queensland, Australia

7. Centre for Molecular & Medical Research, School of Medicine, Deakin University, Geelong, Victoria 3220, Australia

Abstract

Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood and buccal samples. Results: Differentially methylated regions between epilepsy types associated with PM20D1 and GFPT2 genes in both tissues. Within MZ discordant twin pairs, differentially methylated regions associated with OTX1 and ARID5B genes for generalized epilepsy and TTC39C and DLX5 genes for focal epilepsy. Conclusion: This is the first epigenome-wide association study, utilizing the discordant MZ co-twin model, to deepen our understanding of the neurobiology of epilepsy.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0136

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