In vitro susceptibility testing of dermatophytes isolated from pediatric cases in Nigeria against five antifungals

Author:

Nweze E.I.1,Ogbonna C.C.2,Okafor J.I.3

Affiliation:

1. University of Nigeria, Nigeria; Ebonyi State University, Nigeria

2. Ebonyi State University, Nigeria

3. University of Nigeria, Nigeria

Abstract

The antifungal activities of itraconazole, ketoconazole, fluconazole, terbinafine and griseofulvin were tested by broth microdilution methods against 71 isolates of dermatophytes isolated from Nigerian children. Most drugs were very active against all the dermatophytes and the MIC 90 ranged from 0.03 to 8.0 µg/mL. This appears to be the first documented data on the antifungal susceptibility testing of isolates of dermatophytes from Nigerian children.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference18 articles.

1. Quality control limits of broth microdilution susceptibility tests of ten antifungal agents;BARRY A.L.;J. clin. Microbiol.,2000

2. Etiology of dermatophytoses in Cross-River State of Nigeria;EKANEM L.S;Mykosen,1987

3. Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using microdilution assay;FAVRE B.;J. clin. Microbiol.,2003

4. Collaborative evaluation of optimal antifungal susceptibility testing condition for dermatophytes;FERNÁNDEZ-TORRES B.;J. clin. Microbiol.,2002

5. In vitro activities of 10 antifungal drugs against 508 dermatophyte strains;FERNANDEZ-TORRES B.;Antimicrob. Agents Chemother.,2001

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