Basic considerations in the dermatokinetics of topical formulations

Author:

Nair Anroop1,Jacob Shery2,Al-Dhubiab Bandar1,Attimarad Mahesh1,Harsha Sree1

Affiliation:

1. King Faisal University, Kingdom of Saudi Arabia

2. Gulf Medical University, United Arab Emirates

Abstract

Assessing the bioavailability of drug molecules at the site of action provides better insight into the efficiency of a dosage form. However, determining drug concentration in the skin layers following topical application of dermatological formulations is a great challenge. The protocols followed in oral formulations could not be applied for topical dosage forms. The regulatory agencies are considering several possible approaches such as tape stripping, microdialysis etc. On the other hand, the skin bioavailability assessment of xenobiotics is equally important for topical formulations in order to evaluate the toxicity. It is always possible that drug molecules applied on the skin surface may transport thorough the skin and reaches systemic circulation. Thus the real time measurement of molecules in the skin layer has become obligatory. In the last two decades, quite a few investigations have been carried out to assess the skin bioavailability and toxicity of topical/dermatological products. This review provides current understanding on the basics of dermatokinetics, drug depot formation, skin metabolism and clearance of drug molecules from the skin layers following application of topical formulations.

Publisher

FapUNIFESP (SciELO)

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference74 articles.

1. Effects of iontophoresis current magnitude and duration on dexamethasone deposition and localized drug retention;ANDERSON C.R.;Phys. Ther.,2003

2. Ethanol absorption across human skin measured by microdialysis technique;ANDERSON C;Acta Derm. Venereol.,1991

3. Dermal microdialysis sampling in vivo;AULT J.M;Pharm. Res.,1994

4. The design and manufacture of medicines;AULTON M.E.,2007

5. Relevance of equivalence assessment of topical products based on the dermatopharmacokinetics approach;BOIX-MONTANES A;Eur. J. Pharm. Sci.,2011

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3