Author:
Rashed Fatma,Kamijyo Shingo,Shimizu Yuri,Hirohashi Yuna,Khan Masud,Sugamori Yasutaka,Murali Ramachandran,Aoki Kazuhiro
Abstract
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse signaling, wherein RANKL molecules on osteoblasts work as receptors to stimulate osteoblast differentiation. However, why RANKL-binding peptides stimulate osteoblast differentiation while osteoprotegerin (OPG), which is well known to bind to RANKL, cannot activate osteoblast differentiation has remained unclear. In this mini-review, we introduce three main issues: (1) The inhibitory effects of two RANKL-binding peptides (W9 and OP3-4) on bone resorption; (2) The stimulatory effects of the RANKL-binding peptides on osteoblast differentiation; and (3) The accumulation and membrane clustering of RANKL molecules at the cell surface of osteoblasts as a potential molecular switch stimulating osteoblast differentiation by RANKL-binding peptides.
Funder
Company of Biologists
Japan Society for the Promotion of Science London
Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering
Subject
Cell Biology,Developmental Biology
Cited by
8 articles.
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