Targeting the Role of PRME in Regulating Bone Remodelling During Postmenopausal Osteoporosis

Author:

Jalaja Anish Rajamohanan1ORCID,Nair Aswathy12,Bindumadhavan Vijayalakshmi3,Soumya Neelakanta Pillai Padmakumari14,Rauf Arun A.1ORCID

Affiliation:

1. Department of Biochemistry University of Kerala, Kariavattom Campus, Trivandrum Thiruvananthapuram 695581 India Tel.

2. Kerala State Palmyrah Products Development and Workers' Welfare Corporation Limited Trivandrum India

3. Department of Computational Biology and Bioinformatics University of Kerala Trivandrum India

4. Kerala State Animal Husbandry Department, Mararikulam south, Alappuzha Kerala India .

Abstract

AbstractKariavattom Campus Postmenopausal osteoporosis (PMO) is an old age disorder associated with estrogen deficiency, which reduces bone mass and makes bones more prone to fracture. The present study was proposed to evaluate the invivo osteogenic efficiency of Pterospermum rubiginosum methanolic bark extract (PRME) in the PMO model. Molecular docking studies on transcription factor NFATC1 showed excellent interactions with phytochemical ligands with the lowest binding energies. Female Sprague Dawley (SD) rats (n=24) were divided into four groups, (n=6 each) sham control (Group I) and osteoporotic control (Group II) groups treated with saline, PRME (50 mg/kg/day) and alendronate (10 mg/kg/day) treated with Group III and Group IV (n=6) respectively. The serum tartrate‐resistant acid phosphatase 5b and cathepsin‐K also exhibited a significant rise after PRME treatment 12.33±2.30 mU/ml and 427.68±46.97 pg/ml, respectively. DEXA results exhibited a remarkable increase in total bone mineral content and density values in PRME‐treated animals (0.175±0.002 g/cm2) and (7.95±0.23 g) when compared to osteoporotic control (0.163±0.004 g/cm2) and (6.83±0.34 g). Long‐term toxicity study revealed that PRME is non‐toxic, up to 100 mg/kg bodyweight for 6 months. Our findings suggest PRME protects osteoporotic SD rats from PMO damage resulting from estrogen deficiency by regulating bone remodelling markers and upregulating BMD indices.

Publisher

Wiley

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