Author:
Moufarrej Mira N.,Wong Ronald J.,Shaw Gary M.,Stevenson David K.,Quake Stephen R.
Abstract
In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.
Funder
Bill and Melinda Gates Foundation
Subject
Pediatrics, Perinatology, and Child Health
Cited by
27 articles.
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