Noninvasive blood tests for fetal development predict gestational age and preterm delivery-Reference-Cited by-同舟云学术

Noninvasive blood tests for fetal development predict gestational age and preterm delivery

Published:2018-06-08 Issue:6393 Volume:360 Page:1133-1136
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ngo Thuy T. M.¹^ORCID,Moufarrej Mira N.¹^ORCID,Rasmussen Marie-Louise H.²^ORCID,Camunas-Soler Joan¹^ORCID,Pan Wenying¹^ORCID,Okamoto Jennifer¹,Neff Norma F.¹^ORCID,Liu Keli³,Wong Ronald J.⁴^ORCID,Downes Katheryne⁵^ORCID,Tibshirani Robert³⁶^ORCID,Shaw Gary M.⁴^ORCID,Skotte Line²^ORCID,Stevenson David K.⁴,Biggio Joseph R.⁷^ORCID,Elovitz Michal A.⁵^ORCID,Melbye Mads²⁸^ORCID,Quake Stephen R.¹^ORCID

Affiliation:

1. Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA.

2. Department of Epidemiology Research, Statens Serum Institute, Copenhagen 2300, Denmark.

3. Department of Statistics, Stanford University, Stanford, CA 94305, USA.

4. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

6. Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Center for Women’s Reproductive Health, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL 35294, USA.

8. Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Toward more predictable birthdays Low-cost methods for monitoring fetal development could improve prenatal care, especially in low-resource settings. By measuring the levels of certain placental RNA transcripts in maternal blood, Ngo et al. developed two noninvasive blood tests that provide a window into the progression of individual pregnancies. In a small proof-of-concept study, the first blood test predicted fetal age and delivery date with an accuracy comparable to that of ultrasound. The second blood test, also examined in a small pilot study, discriminated women at risk of preterm delivery from those who delivered at full term. The next step will be to assess the reliability of the tests in large, blinded clinical trials. Science , this issue p. 1133

Funder

Bill and Melinda Gates Foundation

March of Dimes Foundation

Chan Zuckerberg Biohub

March of Dimes Prematurity Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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