A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease-Reference-Cited by-同舟云学术

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A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Published:2019-06-19 Issue: Volume:11 Page:
ISSN:1663-4365
Container-title:Frontiers in Aging Neuroscience
language:
Short-container-title:Front. Aging Neurosci.

Author:

Hatat Bérénice,Yahiaoui Samir,Lecoutey Cédric,Davis Audrey,Freret Thomas,Boulouard Michel,Claeysen Sylvie,Rochais Christophe,Dallemagne Patrick

Funder

Fondation Plan Alzheimer

Publisher

Frontiers Media SA

Subject

Cognitive Neuroscience,Ageing

Reference43 articles.

1. Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer’s disease;Baranger;Neuropharmacology,2017

2. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer’s disease;Benhamú;J. Med. Chem.,2014

3. Multi-target-directed ligands to combat neurodegenerative diseases;Cavalli;J. Med. Chem.,2008

4. Activation of 5-HT4 receptors inhibits secretion of β-amyloid peptides and increases neuronal survival;Cho;Exp. Neurol.,2007

5. Serotonin: a new hope in Alzheimer’s disease?;Claeysen;ACS Chem. Neurosci.,2015

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1. The Serotonin 4 Receptor Subtype: A Target of Particular Interest, Especially for Brain Disorders;International Journal of Molecular Sciences;2024-05-11

2. Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia;Journal of Parkinson's Disease;2024-03-05

3. Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease;European Journal of Medicinal Chemistry;2023-12

4. Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer's Disease;ACS OMEGA;2022

5. Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease;ACS Omega;2022-08-30

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