Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia

Author:

Cirillo Rossella12,Duperrier Sandra12,Parekh Pathik123,Millot Mathilde12,Li Qin4,Thiolat Marie-Laure56,Morelli Micaela3,Xie Jing17,Le Bars Didier8,Redouté Jérôme8,Bezard Erwan456,Sgambato Véronique12

Affiliation:

1. Institut des Sciences Cognitives Marc Jeannerod (ISCMJ), Unité Mixte de Recherche 5229 du Centre National de la Recherche Scientifique (CNRS), Bron, France

2. Universitè de Lyon 1, Lyon, France

3. Department of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Monserrato, Italy

4. Motac Beijing Services, Beijing, China

5. Universitè de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France

6. CNRS, Institut des Maladies Neurodégénératives, Bordeaux, France

7. Institut du Vieillissement, Centrede Recherche Clinique Vieillissement Cerveau Fragilité, Hôpital des Charpennes, Villeurbanne, France

8. CERMEP-Imagerie du Vivant, Lyon, France

Abstract

Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson’s disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD’s symptoms.

Publisher

IOS Press

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3