Chronic treatments with a 5-HT 4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

Author:

Baranger Kevin,Giannoni Patrizia,Girard Stéphane D.,Girot Sarah,Gaven Florence,Stephan Delphine,Migliorati Martine,Khrestchatisky Michel,Bockaert Joël,Marchetti-Gauthier Evelyne,Rivera Santiago,Claeysen Sylvie,Roman François S.ORCID

Funder

CNRS

Aix-Marseille Université

French National Agency

A*MIDEX

French Government program

France Alzheimer

La Fondation Vaincre Alzheimer

Inserm

University of Montpellier

French National Agency of Research

Fondation Plan Alzheimer

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference83 articles.

1. Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons;Ansanay;Mol. Pharmacol.,1992

2. Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology;Bachstetter;J. Neurosci.,2012

3. MT5-MMP promotes Alzheimer's pathogenesis in the frontal cortex of 5xFAD mice and APP trafficking in vitro;Baranger;Front. Mol. Neurosci.,2016

4. MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease;Baranger;Cell Mol. Life Sci.,2016

5. Endogenous and synthetic MMP inhibitors in CNS physiopathology;Baranger;Prog. Brain Res.,2014

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