Author:
Llaha Fjorida,Cayssials Valerie,Farràs Marta,Agudo Antonio,Sandström Maria,Eriksen Anne Kirstine,Tjønneland Anne,Boutron-Ruault Marie-Christine,Laouali Nasser,Truong Thérèse,Le Cornet Charlotte,Katzke Verena,Schulze Matthias,Palli Domenico,Krogh Vittorio,Signoriello Simona,Tumino Rosario,Ricceri Fulvio,Skeie Guri,Jensen Torill Miriam Enget,Chen Sairah Lai Fa,Lasheras Cristina,Rodriguez-Barranco Miguel,Amiano Pilar,Huerta José María,Guevara Marcela,Almquist Martin,Nilson Lena Maria,Hennings Joakim,Papier Keren,Heath Alicia,Weiderpass Elisabete,Rinaldi Sabina,Zamora-Ros Raul
Abstract
BackgroundThe Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.MethodsOver 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors.ResultsAdherence to the arMED score was not associated with the risk of differentiated TC (HRhigh vs. low adherence = 0.94, 95% CI: 0.70–1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HRhigh vs. low adherence = 0.88, 95% CI: 0.68–1.14; p-trend 0.17). Low meat (HRlow vs. high meat intake = 0.81, 95% CI: 0.67–0.99; p-trend = 0.04) and moderate alcohol (HRmoderate vs. non−moderate intake = 0.88, 95% CI: 0.75–1.03) intake were related with lower differentiated TC risk.ConclusionsOur study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.
Funder
Instituto de Salud Carlos III
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Food Science
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献