Synthesis of Imidazole-Based Molecules under Ultrasonic Irradiation Approaches
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Published:2023-06-19
Issue:12
Volume:28
Page:4845
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Yu Xian-Long12, Fan Yu-Han3, Zheng Xu-Nan2, Gao Jing-Fei2, Zhuang Li-Geng2, Yu Yang-Ling2, Xi Jing-Hui2, Zhang Da-Wei1ORCID
Affiliation:
1. College of Chemistry, Jilin University, Changchun 130012, China 2. College of Plant Science, Jilin University, Changchun 130062, China 3. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
Abstract
Imidazole-based compounds are a series of heterocyclic compounds that exhibit a wide range of biological and pharmaceutical activities. However, those extant syntheses using conventional protocols can be time-costly, require harsh conditions, and result in low yields. As a novel and green technique, sonochemistry has emerged as a promising method for organic synthesis with several advantages over conventional methods, including enhancing reaction rates, improving yields, and reducing the use of hazardous solvents. Contemporarily, a growing body of ultrasound-assisted reactions have been applied in the preparation of imidazole derivatives, which demonstrated greater benefits and provided a new strategy. Herein, we introduce the brief history of sonochemistry and focus on the discussion of the multifarious approaches for the synthesis of imidazole-based compounds under ultrasonic irradiation and its advantages in comparison with conventional protocols, including typical name-reactions and various sorts of catalysts in those reactions.
Funder
Science and Technology Planning Project of the Jilin Province National Key R&D Program of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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