Abstract
Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia act as antennae to sense a cell’s environment and are involved in a wide range of signaling pathways essential for development. Motile cilia drive cell locomotion or liquid flow around the cell. Proper functioning of both types of cilia requires a highly orchestrated bi-directional transport system, intraflagellar transport (IFT), which is driven by motor proteins, kinesin-2 and IFT dynein. In this review, we explore how IFT is regulated in cilia, focusing from three different perspectives on the issue. First, we reflect on how the motor track, the microtubule-based axoneme, affects IFT. Second, we focus on the motor proteins, considering the role motor action, cooperation and motor-train interaction plays in the regulation of IFT. Third, we discuss the role of kinases in the regulation of the motor proteins. Our goal is to provide mechanistic insights in IFT regulation in cilia and to suggest directions of future research.
Funder
European Research Council
European Commission
Reference208 articles.
1. Antony van Leeuwenhoek and his “Little Animals”: Being Some Account of the Father of Protozoology and Bacteriology and his Multifarious Discoveries in these Disciplines;Dobell,1932
2. Phosphoinositide lipids in primary cilia biology
3. The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.
4. Evolution of Cilia
5. How did the cilium evolve?;Satir;Curr. Top. Dev. Biol.,2008
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献