Emerging principles of primary cilia dynamics in controlling tissue organization and function

Author:

Gopalakrishnan Jay1ORCID,Feistel Kerstin2ORCID,Friedrich Benjamin M3,Grapin‐Botton Anne345ORCID,Jurisch‐Yaksi Nathalie6ORCID,Mass Elvira7ORCID,Mick David U8ORCID,Müller Roman‐Ulrich910ORCID,May‐Simera Helen11,Schermer Bernhard910,Schmidts Miriam1213ORCID,Walentek Peter1314,Wachten Dagmar15ORCID

Affiliation:

1. Institute for Human Genetics, Heinrich‐Heine‐Universität Universitätsklinikum Düsseldorf Düsseldorf Germany

2. Department of Zoology, Institute of Biology University of Hohenheim Stuttgart Germany

3. Cluster of Excellence Physics of Life, TU Dresden Dresden Germany

4. Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany

5. Paul Langerhans Institute Dresden of the Helmholtz Center Munich at The University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden Dresden Germany

6. Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway

7. Life and Medical Sciences Institute, Developmental Biology of the Immune System University of Bonn Bonn Germany

8. Center for Molecular Signaling (PZMS), Center of Human and Molecular Biology (ZHMB) Saarland School of Medicine Homburg Germany

9. Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

10. Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

11. Institute of Molecular Physiology Johannes Gutenberg‐University Mainz Germany

12. Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine University Hospital Freiburg Freiburg Germany

13. CIBSS‐Centre for Integrative Biological Signalling Studies University of Freiburg Freiburg Germany

14. Renal Division, Internal Medicine IV, Medical Center University of Freiburg Freiburg Germany

15. Institute of Innate Immunity, Biophysical Imaging, Medical Faculty University of Bonn Bonn Germany

Abstract

AbstractPrimary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context‐dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell‐ and tissue‐specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.

Funder

Bundesministerium für Bildung und Forschung

Marga und Walter Boll-Stiftung

PKD Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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