Cilia‐related diseases

Author:

Ren Zhanhong1,Mao Xiaoxiao12,Wang Siqi1,Wang Xin3

Affiliation:

1. Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology Xianning P. R. China

2. School of Basic Medical Sciences Xianning Medical College, Hubei University of Science and Technology Xianning P. R. China

3. School of Mathematics and Statistics Hubei University of Science and Technology Xianning P. R. China

Abstract

AbstractMore and more attention is paid to diseases such as internal transfer and brain malformation which are caused by the abnormal morphogenesis of cilia. These cilia‐related diseases are divided into two categories: ciliopathy resulting from defects of primary cilia and primary ciliary dyskinesia (PCD) caused by functional dysregulation of motile cilia. Cilia are widely distributed, and their related diseases can cover many human organs and tissues. Recent studies prove that primary cilia play a key role in maintaining homeostasis in the cardiovascular system. However, molecular mechanisms of cilia‐related diseases remain elusive. Here, we reviewed recent research progresses on characteristics, molecular mechanisms and treatment methods of ciliopathy and PCD. Our review is beneficial to the further research on the pathogenesis and treatment strategies of cilia‐related diseases.

Funder

Natural Science Foundation of Hubei Province

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

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