Impact of Green Extraction on Curcuminoid Content, Antioxidant Activities and Anti-Cancer Efficiency (In Vitro) from Turmeric Rhizomes (Curcuma longa L.)

Author:

Singh Kanjana,Srichairatanakool SomdetORCID,Chewonarin TeeraORCID,Prommaban Adchara,Samakradhamrongthai Rajnibhas SukeawORCID,Brennan Margaret Anne,Brennan Charles StephenORCID,Utama-ang Niramon

Abstract

Turmeric (Curcuma longa L.) powder is widely used as a spice and seasoning in Asian countries. This study investigated the effect of turmeric extracts on the anticancer activity of Huh7 and HCT 116 cells. The curcumin bioactive compounds were extracted using various methods such as microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE) and traditional extraction (TDE). The yield of dried extracts from MAE was found to be the highest at 17.89%, followed by UAE and TDE, with 11.34% and 5.54%, respectively. Antioxidant activities such as TPC, DPPH and FRAP from MAE were higher than those of UAE and TDE. The total curcuminoid contents from the novel extractions were higher than those from traditional extraction methods. For instance, curcuminoid contents from MAE, UAE and TDE were 326.79, 241.17 and 215.83 mg/g, respectively. Due to having the highest bioactive compounds and extraction yield, turmeric extract from MAE was used to investigate the potential anticancer properties. The extract showed significant cytotoxic potential against the human liver (Huh7) and human colon (HCT116) cell lines, in concentrations ranging from 31.25 to 1000.00 µg/mL. Turmeric extracts using MAE have potential anticancer effects on Huh7 and HCT116 cells. This study serves as scientific data for the chemotherapeutic properties of turmeric extracts and their use as functional ingredients.

Funder

Research and Researchers for Industries scholarship

Publisher

MDPI AG

Subject

Plant Science,Health Professions (miscellaneous),Health (social science),Microbiology,Food Science

Reference38 articles.

1. Antitumoral Efficacy of Two Turmeric Extracts According to Different Extraction Methods in Hepatocellular Carcinoma Cell Lines;J. Med. Aromat.,2018

2. Phenolic Composition, Antiproliferative and Antiulcerogenic Activities of a Polyphenol-Rich Purified Extract from Acai (Euterpe oleracea) Fruits;Int. J. Food Sci. technol.,2021

3. Anti-proliferative Activities, Phytochemical Levels and Fruit Quality of Pepper (Capsicum spp.) Following Prolonged Storage;Int. J. Food Sci. Technol.,2020

4. Antioxidant and Apoptotic Potential of Protein Isolates Derived from Vigna unguiculata (L.) Walp;Int. J. Food Sci. Technol.,2020

5. Cold Atmospheric-Pressure Plasma Treatment of Turmeric Powder: Microbial Load, Essential Oil Profile, Bioactivity and Microstructure Analyses;Int. J. Food Sci. Technol.,2020

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