Genetics in Ischemic Stroke: Current Perspectives and Future Directions-Reference-Cited by-同舟云学术

Genetics in Ischemic Stroke: Current Perspectives and Future Directions

Published:2023-12-13 Issue:12 Volume:10 Page:495
ISSN:2308-3425
Container-title:Journal of Cardiovascular Development and Disease
language:en
Short-container-title:JCDD

Author:

Zhang Ka¹,Loong Shaun²³^ORCID,Yuen Linus³,Venketasubramanian Narayanaswamy⁴^ORCID,Chin Hui-Lin⁵,Lai Poh⁶,Tan Benjamin¹³

Affiliation:

1. Division of Neurology, Department of Medicine, National University Hospital, Singapore 119074, Singapore

2. Cardiovascular-Metabolic Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore

3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore

4. Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, Singapore

5. Khoo Teck Puat National University Children’s Medical Institute, National University Hospital, Singapore 119074, Singapore

6. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore

Abstract

Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke occurrence risk, modulation of treatment response, and effectiveness of post-stroke functional recovery. This article aims to review the recent findings from genetic studies related to various clinical and molecular aspects of ischemic stroke. The potential clinical applications of these genetic insights in stratifying stroke risk, guiding personalized therapy, and identifying new therapeutic targets are discussed herein.

Publisher

MDPI AG

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

https://www.mdpi.com/2308-3425/10/12/495/pdf

Reference127 articles.

1. GBD 2019 Stroke Collaborators (2021). Global, regional, and national burden of stroke and its risk factors, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol., 20, 795–820.

2. Familial history of stroke and stroke risk. The Family Heart Study;Liao;Stroke,1997

3. Familial risk and heritability of ischemic heart disease and stroke in Danish twins;Osler;Scand. J. Public Health,2022

4. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations;Bevan;Stroke,2012

5. Chojdak-Lukasiewicz, J., Dziadkowiak, E., and Budrewicz, S. (2021). Monogenic Causes of Strokes. Genes, 12.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Insilico Analysis of Alpha-1 Antitrypsin Pathway in Ischemic Stroke Patients;2024-08-05