Abstract
Ischemic stroke is one of the types of strokes related to the low oxygen supply to the brain cells. It is subdivided into cardioembolic stroke, large artery atherosclerosis stroke, small vessel occlusion and cryptogenic stroke. The stroke is symptomized by body weakness or paralysis on one side. Its development is correlated to the genetic variations of the SERPINA1 gene that produces variants such as Z-allele variant where glutamic acid is replaced with lysine, S-allele variant where glutamic is replaced by valine and the normal M-allele variant which leads to the synthesis of less amount of AAT coupled with its deficiency (AATD) and lowering of AAT activity against the neutrophil elastase that degrades elastin in the lung tissue reducing the permeation of oxygen to the blood stream. In this study, various computational tools such as Heartbio portal, genotype-tissue expression platforms have been employed to retrieve data that relates to the stroke. The pathways in which SERPINA1 participates are identified and the genes involved in them with a regulation activity relating to the stroke were analyzed. The identified genes can be applied as biomarkers to trace the potential development of the stroke in patients with cardiovascular diseases, diabetes, obesity and others. Additionally, the genes can be employed in the therapeutical treatments of the stroke patients.