Affiliation:
1. From the Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill (D.L., C.P., G.H.); Section of Preventive Medicine and Epidemiology, University Hospital, Boston, Mass (R.M.); Cardiovascular Genetics, University of Utah, Salt Lake City (S.H.); Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (E.S.); Department of Public Health Sciences, Bowman-Gray School of Medicine, Winston-Salem, NC (G.B.); and Division of...
Abstract
Background and Purpose
Although familial history of stroke is generally perceived to be an important marker of stroke risk, very few epidemiological studies have been published to address this hypothesis. We sought to examine whether familial history of stroke is associated with the prevalence of stroke in the Family Heart Study, a National Heart, Lung, and Blood Institute–supported multicenter study of the familial, genetic, and nongenetic determinants of cardiovascular disease in populations.
Methods
The personal and familial histories of stroke were assessed in 3168 individuals (probands) who were at least 45 years old and 29 325 of their first-degree relatives with the use of a standardized questionnaire.
Results
The age-, ethnicity-, and sex-adjusted stroke prevalences were 4.8%, 4.9%, and 3.9% in probands with a positive familial, paternal, and maternal history of stroke, respectively, in comparison with 2.0% in probands without any positive familial history (
P
<.01). The age-, ethnicity-, and sex-adjusted odds ratios (95% confidence interval) of stroke were 2.00 (1.13, 3.54) for a positive paternal and 1.41 (0.80, 2.50) for a positive maternal history of stroke. Additional statistical adjustment for the proband’s history of elevated cholesterol level, cigarette smoking status, history of coronary heart disease, hypertension, and diabetes did not alter the associations. A similar pattern was seen for African Americans and European Americans.
Conclusions
The increased risk of stroke among persons with a positive familial history of stroke compared with those without a familial history of stroke is consistent with the expression of genetic susceptibility, a shared environment, or both in the etiology of stroke.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Cited by
164 articles.
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