Abstract
Herein, gold nanoclusters (Au NC) dispersed on gold dendrite (Au DS)-based flexible carbon fibre (AuNC@AuDS|CF) microelectrodes are developed using a one-step electrochemical approach. The as-fabricated AuNC@AuDS|CF microelectrodes work as the prospective electrode materials for the sensitive detection of nitric oxide (NO) in a 0.1 M phosphate buffer (PB) solution. Carbon microfibre acts as an efficient matrix for the direct growth of AuNC@AuDS without any binder/extra reductant. The AuNC@AuDS|CF microelectrodes exhibit outstanding electrocatalytic activity towards NO oxidation, which is ascribed to their large electrochemical active surface area (ECSA), high electrical conductivity, and high dispersion of Au nanoclusters. As a result, the AuNC@AuDS|CF microelectrodes attain a rapid response time (3 s), a low limit of detection (LOD) (0.11 nM), high sensitivity (66.32 µA µM cm−2), a wide linear range (2 nM–7.7 µM), long-term stability, good reproducibility, and a strong anti-interference capability. Moreover, the present microsensor successfully tested for the discriminating detection of NO in real human serum samples, revealing its potential practicability.
Subject
Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)
Cited by
10 articles.
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