A Novel Tetrapeptide Ala-Phe-Phe-Pro (AFFP) Derived from Antarctic Krill Prevents Scopolamine-Induced Memory Disorder by Balancing Lipid Metabolism of Mice Hippocampus

Author:

Yang Jingqi12,Qi Yan12,Zhu Beiwei3,Lin Songyi124

Affiliation:

1. SKL of Marine Food Processing & Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China

2. Engineering Research Center of Food, Dalian Polytechnic University, Dalian 116034, China

3. National Engineering Research Center of Seafood, Dalian 116034, China

4. Engineering Research Center of Special Dietary Food, The Education Department of Liaoning Province, Dalian 116034, China

Abstract

Memory impairment is a serious problem with organismal aging and increased social pressure. The tetrapeptide Ala-Phe-Phe-Pro (AFFP) is a synthetic analogue of Antarctic krill derived from the memory-improving Antarctic krill peptide Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg (SSDAFFPFR) after digestion and absorption. The objective of this research was to assess the neuroprotective effects of AFFP by reducing oxidative stress and controlling lipid metabolism in the brains of mice with memory impairment caused by scopolamine. The 1H Nuclear magnetic resonance spectroscopy results showed that AFFP had three active hydrogen sites that could contribute to its antioxidant properties. The findings from in vivo tests demonstrated that AFFP greatly enhanced the mice’s behavioral performance in the passive avoidance, novel object recognition, and eight-arm maze experiments. AFFP reduced oxidative stress by enhancing superoxide dismutase activity and malondialdehyde levels in mice serum, thereby decreasing reactive oxygen species level in the mice hippocampus. In addition, AFFP increased the unsaturated lipid content to balance the unsaturated lipid level against the neurotoxicity of the mice hippocampus. Our findings suggest that AFFP emerges as a potential dietary intervention for the prevention of memory impairment disorders.

Funder

National Key Research and Development Program of China

Publisher

MDPI AG

Reference70 articles.

1. Sleep facilitates memory by blocking dopamine neuron-mediated forgetting;Berry;Cell,2015

2. Effect of anchovy (Coilia mystus) protein hydrolysate and its Maillard reaction product on combating memoryimpairment in mice;Su;Food Res. Int.,2016

3. Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice;Wang;RSC Adv.,2018

4. Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse;Sasaki;J. Agric. Food Chem.,2013

5. United Nations, Department of Economic and Social Affairs, Population Division (2019, November 19). World Population Prospects: The 2017 Revision, Key Findings and Advance Tables. Working Paper No. ESA/P/WP/248. Available online: https://population.un.org/wpp/Publications/Files/WPP2017_KeyFindings.pdf.

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