Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease-Reference-Cited by-同舟云学术

Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease

Published:2023-02-26 Issue:3 Volume:12 Page:584
ISSN:2076-3921
Container-title:Antioxidants
language:en
Short-container-title:Antioxidants

Author:

Dozio Elena¹^ORCID,Caldiroli Lara²^ORCID,Molinari Paolo²^ORCID,Castellano Giuseppe²³,Delfrate Nicholas Walter²,Romanelli Massimiliano Marco Corsi¹⁴^ORCID,Vettoretti Simone²^ORCID

Affiliation:

1. Department of Biomedical Science for Health, Università degli Studi di Milano, 20133 Milan, Italy

2. Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy

3. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy

4. Service of Laboratory Medicine1-Clinical Pathology, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy

Abstract

Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.

Funder

Italian Ministry of Health-Current research IRCCS

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

Link

https://www.mdpi.com/2076-3921/12/3/584/pdf

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