Suitability of Different Blood-Analogous Fluids in Determining the Pump Characteristics of a Ventricular Assist Device

Author:

Knüppel Finn1ORCID,Thomas Inga1,Wurm Frank-Hendrik1,Torner Benjamin1ORCID

Affiliation:

1. Institute of Turbomachinery, University of Rostock, Albert-Einstein-Straße 2, 18059 Rostock, Germany

Abstract

Ventricular assist devices (VADs) are implantable turbomachines that save and improve the lives of patients with severe heart failure. In the preclinical evaluation, a VAD design must be experimentally or numerically tested regarding its pump characteristics, primarily for its pressure buildup (pressure head H) since it must provide the cardiovascular system with a sufficient blood flow rate Q. Those pump characteristics are determined on a test bench. Here, a glycerol-water mixture is almost exclusively used as blood-analogous fluid, which should reflect the properties (density, viscosity) of blood as close as possible. However, glycerol water has some disadvantages, such as a higher density compared to real blood and a relatively high cost. Therefore, the study aimed to analyze six different blood analogous fluids to select the most suitable one in consideration of fluid handling, costs, and, most importantly, fluid properties (material and rheological). First, all fluids were mixed to achieve reference values of blood density and viscosity from the literature. Afterwards, the pump characteristics (pressure heads and efficiencies via the VAD) were experimentally and numerically determined and compared among each other and with literature values. Of all six investigated fluids, only the aqueous–polyethylene glycol 200 (PEG 200) solution matches exactly the desired blood properties, and the pump characteristics of this fluid are in the expected range for the analyzed operation point of the VAD. Another advantage is that the cost of the mixture is 35% lower compared to glycerol water. Additionally, we demonstrate that non-Newtonian flow behavior has little effect on the pump characteristics in our VAD.

Funder

German Research Foundation

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Mechanical Engineering,Condensed Matter Physics

Reference35 articles.

1. Global epidemiology and future trends of heart failure;Gomar;AME Med. J.,2020

2. Waage, P., Kreuter, D.P., and Blome, B. (2023, January 17). Annual Report—Organ Donation and-Transplantation in Germany; Deutsche Stiftung Organtransplantation. Available online: https://dso.de/SiteCollectionDocuments/DSO-Jahresbericht%202021.pdf.

3. The Society of Thoracic Surgeons Intermacs 2019 annual report: The changing landscape of devices and indications;Teuteberg;Ann. Thorac. Surg.,2020

4. Gülich, J.F. (2014). Centrifugal Pumps, Springer.

5. Investigation of fluid dynamics within a miniature mixed flow blood pump;Wu;Exp. Fluids,2001

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3