Colorectal Cancer: 35 Cases in Asbestos-Exposed Workers

Author:

Porzio Antonietta12ORCID,Feola Alessandro1ORCID,Parisi Giuseppe1,Lauro Angelo3,Campobasso Carlo Pietro1ORCID

Affiliation:

1. Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, 80138 Naples, Italy

2. Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, 80138 Naples, Italy

3. Regional Directorate Campania, National Institute for Insurance against Accidents at Work (INAIL), 80143 Napoli, Italy

Abstract

Background: Asbestos is considered one of the major global work-related carcinogens. Some studies suggest a potential causal relationship between asbestos exposure and colorectal cancer (CRC). However, the role of asbestos in CRC carcinogenesis is still controversial. Methods: 35 claims of occupational CRC among asbestos-exposed workers were reviewed. All claims were rejected by the Italian National Institute for Insurance against Accidents (INAIL) due to the “lack of scientific evidence in the causality” between asbestos exposure and CRC; causality was finally assessed in civil trials. All cases were categorized by age, gender, industry type, task, exposure and latency periods, anatomical location, and histopathological characteristics of CRC and concomitant respiratory diseases. Results: Most workers were males aged 60 years or more and employed in occupational activities with extensive use of asbestos for over 20 years. In 31 out of 35 cases, CRC was diagnosed over 39 years after employment. Right-sided colic adenocarcinoma was diagnosed in nine cases; rectum was involved in eight cases. Respiratory comorbidities were observed in 22 workers. Conclusions: Our study provides some interesting points in the assessment of the causal relationship between asbestos exposure and CRC.

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

Reference80 articles.

1. GBD 2017 Risk Factors Collaborators (2018). Global, regional and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Diseases Study 2017. Lancet, 392, 1923–1994.

2. World Health Organization (2006). Overview: Elimination of Asbestos-Related Diseases, World Health Organization.

3. Fazzo, L., Binazzi, A., Ferrante, D., Minelli, G., Consonni, D., Bauleo, L., Bruno, C., Bugani, M., De Santis, M., and Iavarone, I. (2021). Burden of Mortality from Asbestos-Related Diseases in Italy. Int. J. Environ. Res. Public Health, 18.

4. Global magnitude of reported and unreported mesothelioma;Park;Environ. Health Perspect.,2011

5. The ecological association between asbestos consumption and asbestos-related diseases 15 years later;Rath;Environ. Health Perspect.,2022

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3