Colorectal Cancer and Asbestos Exposure: A Women’s Health Perspective

Author:

Porzio Antonietta12,Feola Alessandro3ORCID,Salzillo Cecilia4ORCID,Corbi Graziamaria5ORCID,Campobasso Carlo Pietro3ORCID

Affiliation:

1. Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, 80138 Naples, Italy

2. Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, National Institute for Workers’ Compensation (INAIL), 00143, Rome, Italy

3. Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, 80138 Naples, Italy

4. Department of Precision and Regenerative Medicine and Ionian Area, Pathology Unit, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70121 Bari, Italy

5. Department of Translational Medical Sciences, University of Naples “Federico II”, 80138 Naples, Italy

Abstract

Background: Colorectal cancer (CRC) is considered a “man’s disease”. However, emerging data show that females may have a higher prevalence of certain risk factors. A potential causal role of asbestos in CRC carcinogenesis has been suggested. This relationship is controversial, and only a few studies have focused on exposed female populations. The aim of this study was to review the scientific literature related to asbestos-related CRC incidence and mortality rates in female populations to address gender bias in the existing research. Methods: A systematic review was performed following PRISMA statement. Results: Fourteen studies reporting 92 cases in total were included. Most women were aged 50 years or older and were employed in occupational activities with high asbestos exposure (steel, textile, and asbestos-cement industry) for at least 10 years. In one single case, household asbestos exposure was reported. The colon was the primary location of the tumor in 47 out of 92 cases. Three women were also affected by synchronous or metachronous peritoneal mesotheliomas. Conclusions: This study revealed a general methodological “gender bias” in scientific research. A significantly higher representation of women in clinical studies is needed to clarify the link between asbestos exposure and the development of colorectal cancer.

Publisher

MDPI AG

Reference59 articles.

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3. Beretta, G., Gori, S., Mantellini, P., Masocco, M., Rugge, M., Sapino, A., and Serraino, D. (2021). I Numeri del Cancro in Italia 2021, AIOM (Associazione Italiana di Oncologia Medica).

4. Colorectal Cancer Risks According to Sex Differences in Patients with Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study;Lee;Clin. Transl. Gastroenterol.,2019

5. The Asia-Pacific Colorectal Screening score: A validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects;Yeoh;Gut,2011

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