Affiliation:
1. Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
2. College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract
Targeted drug delivery using micro-nano robots (MNRs) is a rapidly advancing and promising field in biomedical research. MNRs enable precise delivery of drugs, addressing a wide range of healthcare needs. However, the application of MNRs in vivo is limited by power issues and specificity in different scenarios. Additionally, the controllability and biological safety of MNRs must be considered. To overcome these challenges, researchers have developed bio-hybrid micro-nano motors that offer improved accuracy, effectiveness, and safety for targeted therapies. These bio-hybrid micro-nano motors/robots (BMNRs) use a variety of biological carriers, blending the benefits of artificial materials with the unique features of different biological carriers to create tailored functions for specific needs. This review aims to give an overview of the current progress and application of MNRs with various biocarriers, while exploring the characteristics, advantages, and potential hurdles for future development of these bio-carrier MNRs.
Funder
National Key Research and Development Program of China
Shanghai Sailing Program
National Natural Science Foundation of China
Subject
Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering
Reference102 articles.
1. Feng, A., Cheng, X., Huang, X., Liu, Y., He, Z., Zhao, J., Duan, H., Shi, Z., Guo, J., and Wang, S. (2023). Engineered Organic Nanorockets with Light-Driven Ultrafast Transportability for Antitumor Therapy. Small, e2206426.
2. A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma;Chen;Nat. Commun.,2023
3. Augmented efficacy of nano-formulated docetaxel plus curcumin in orthotopic models of neuroblastoma;Pastorino;Pharmacol. Res.,2023
4. Reconfigurable magnetic microrobot swarm: Multimode transformation, locomotion, and manipulation;Xie;Sci. Robot.,2019
5. Controlled In Vivo Swimming of a Swarm of Bacteria-Like Microrobotic Flagella;Servant;Adv. Mater.,2015
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