Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity-Reference-Cited by-同舟云学术

Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity

Published:2021-01-29 Issue:3 Volume:22 Page:1337
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Zippilli Claudio,Botta Lorenzo^ORCID,Bizzarri Bruno Mattia^ORCID,Nencioni Lucia^ORCID,De Angelis Marta^ORCID,Protto Virginia,Giorgi Gianluca^ORCID,Baratto Maria Camilla^ORCID,Pogni Rebecca^ORCID,Saladino Raffaele^ORCID

Abstract

Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/22/3/1337/pdf

Reference56 articles.

1. Biological and pharmacological activities of amaryllidaceae alkaloids

2. Natural Product Inhibitors of Acetylcholinesterase

3. Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors

4. Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

5. Synthesis, biological evaluation and molecular modeling studies of substitutedN-benzyl-2-phenylethanamines as cholinesterase inhibitors

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer;ACS Chemical Neuroscience;2024-04-18

2. A survey of supramolecular association involving the oxide-O atom in the crystals of triorganoamine N-oxide derivatives, RR′R″N⁽⁺⁾O⁽⁻⁾;Zeitschrift für Kristallographie - Crystalline Materials;2024-03-01

3. Transcriptomic and Phytohormone Metabolomics Provide Insight into the Changes in Citrus limon Infected by Citrus yellow vein clearing virus;Horticulturae;2024-02-28

4. Biotransformation of 1,4-Dioxane by the Use of Bacteria in the Soil;Land Remediation and Management: Bioengineering Strategies;2023

5. Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents;Catalysts;2022-01-25