Synthesis, biological evaluation and molecular modeling studies of substitutedN-benzyl-2-phenylethanamines as cholinesterase inhibitors-Reference-Cited by-同舟云学术

Synthesis, biological evaluation and molecular modeling studies of substitutedN-benzyl-2-phenylethanamines as cholinesterase inhibitors

Published:2020 Issue:22 Volume:44 Page:9466-9476
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Carmona-Viglianco Florencia¹²³⁴⁵^ORCID,Zaragoza-Puchol Daniel⁶⁷⁸⁹¹⁰^ORCID,Parravicini Oscar¹¹²³⁴⁵^ORCID,Garro Adriana¹¹²³⁴⁵^ORCID,Enriz Ricardo D.¹¹²³⁴⁵^ORCID,Feresin Gabriela E.⁶⁷⁸⁹¹⁰^ORCID,Kurina-Sanz Marcela¹²³⁴⁵^ORCID,Orden Alejandro A.¹²³⁴⁵^ORCID

Affiliation:

1. INTEQUI CONICET

2. Facultad de Química Bioquímica y Farmacia

3. Universidad Nacional de San Luis

4. San Luis

5. Argentina

6. Instituto de Biotecnología

7. CONICET

8. Facultad de Ingeniería

9. Universidad Nacional de San Juan.

10. San Juan

11. IMIBIO-SL CONICET

Abstract

4’-O-methylnorbelladine and other non-natural halogenated protoalkaloids were synthesized by reductive amination. They exerted moderate to good inhibition of cholinesterases which was adequately explained by molecular modeling studies.

Funder

Universidad Nacional de San Juan

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Universidad Nacional de San Luis

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ00282H

Reference54 articles.