Synthesis, biological evaluation and molecular modeling studies of substitutedN-benzyl-2-phenylethanamines as cholinesterase inhibitors

Author:

Carmona-Viglianco Florencia12345ORCID,Zaragoza-Puchol Daniel678910ORCID,Parravicini Oscar112345ORCID,Garro Adriana112345ORCID,Enriz Ricardo D.112345ORCID,Feresin Gabriela E.678910ORCID,Kurina-Sanz Marcela12345ORCID,Orden Alejandro A.12345ORCID

Affiliation:

1. INTEQUI CONICET

2. Facultad de Química Bioquímica y Farmacia

3. Universidad Nacional de San Luis

4. San Luis

5. Argentina

6. Instituto de Biotecnología

7. CONICET

8. Facultad de Ingeniería

9. Universidad Nacional de San Juan.

10. San Juan

11. IMIBIO-SL CONICET

Abstract

4’-O-methylnorbelladine and other non-natural halogenated protoalkaloids were synthesized by reductive amination. They exerted moderate to good inhibition of cholinesterases which was adequately explained by molecular modeling studies.

Funder

Universidad Nacional de San Juan

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Universidad Nacional de San Luis

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3