Abstract
Radiosensitizers have proven to be an effective method of improving radiotherapy outcomes, with the distribution of particles being a crucial element to delivering optimal treatment outcomes due to the short range of effect of these particles. Here we present a computational model for the transport of nanoparticles within the tumour, whereby the fluid velocity and particle deposition are obtained and used as input into the convection-diffusion equation to calculate the spatio-temporal concentration of the nanoparticles. The effect of particle surface charge and injection locations on the distribution of nanoparticle concentration within the interstitial fluid and deposited onto cell surfaces is assessed. The computational results demonstrate that negatively charged particles can achieve a more uniform distribution throughout the tumour as compared to uncharged or positively charged particles, with particle volume within the fluid being 100% of tumour volume and deposited particle volume 44.5%. In addition, varying the injection location from the end to the middle of the tumour caused a reduction in particle volume of almost 20% for negatively charged particles. In conclusion, radiosensitizing particles should be negatively charged to maximise their spread and penetration within the tumour. Choosing an appropriate injection location can further improve the distribution of these particles.
Reference45 articles.
1. Nanoparticles in Radiation Therapy: A Summary of Various Approaches to Enhance Radiosensitization in Cancer;Transl. Cancer Res.,2013
2. Caddy, G., Stebbing, J., Wakefield, G., and Xu, X.Y. (2022). Modelling of Nanoparticle Distribution in a Spherical Tumour during and Following Local Injection. Pharmaceutics, 14.
3. Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise;Curr. Mol. Med.,2010
4. Nanoparticle Augmented Radiotherapy Using Titanium Oxide Nanoparticles;J. Nanomater. Mol. Nanotechnol.,2018
5. Iodine Nanoparticles Enhance Radiotherapy of Intracerebral Human Glioma in Mice and Increase Efficacy of Chemotherapy;Sci. Rep.,2019
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献