Glucocorticoid Receptor Point Mutation V571M Facilitates Coactivator and Ligand Binding by Structural Rearrangement and Stabilization
Author:
Affiliation:
1. Department of Structural Biology (P.C., K.F.K.), S-141 57 Huddinge, Sweden
2. Karo Bio AB, Novum, and Department of Biosciences at Novum (P.C., L.N.), Karolinska Institutet, S-141 57 Huddinge, Sweden
Publisher
The Endocrine Society
Subject
Endocrinology,Molecular Biology,General Medicine
Link
http://academic.oup.com/mend/article-pdf/19/8/1960/8951359/mend1960.pdf
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3. Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells.;Kunz;Mol Endocrinol,2003
4. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.;Bledsoe;Cell,2002
5. The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain-RU-486 induces a transconformation that leads to active antagonism.;Kauppi;J Biol Chem,2003
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