Affiliation:
1. Department of Pharmacology and Therapeutics, Faculty of Pharmacy Kuwait University Safat Kuwait
2. Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences Khalifa University Abu Dhabi United Arab Emirates
3. Center for Biotechnology Khalifa University of Science and Technology Abu Dhabi United Arab Emirates
4. Department of Physiology, College of Medicine and Health Sciences UAE University Al Ain United Arab Emirates
Abstract
AbstractCapsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including analgesia, anticancer, anti‐inflammatory, antiobesity, and antioxidant effects. The transient receptor potential vanilloid subfamily member 1 (TRPV1) is the main receptor mediating the majority of the capsaicin effects. However, numerous studies suggest that the TRPV1 receptor is not the only target for capsaicin. An increasing number of studies indicates that capsaicin, at low to mid µM ranges, not only indirectly through TRPV1‐mediated Ca2+ increases, but also directly modulates the functions of voltage‐gated Na+, K+, and Ca2+ channels, as well as ligand‐gated ion channels and other ion transporters and enzymes involved in cellular excitability. These TRPV1‐independent effects are mediated by alterations of the biophysical properties of the lipid membrane and subsequent modulation of the functional properties of ion channels and by direct binding of capsaicin to the channels. The present study, for the first time, systematically categorizes this diverse range of non‐TRPV1 targets and discusses cellular and molecular mechanisms mediating TRPV1‐independent effects of capsaicin in excitable, as well as nonexcitable cells.
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
1 articles.
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