Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells-Reference-Cited by-同舟云学术

Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells

Published:2016-12-05 Issue:5 Volume:31 Page:e21884
ISSN:1095-6670
Container-title:Journal of Biochemical and Molecular Toxicology
language:en
Short-container-title:J Biochem Mol Toxicol

Author:

Li Yuhua¹²,Huang Ling³,Sun Jiahong²,Wei Xiaohua¹,Wen Jinhua¹,Zhong Guoping²,Huang Min²,Bi Huichang²

Affiliation:

1. Department of Pharmacy; The First Affiliated Hospital of Nanchang University; Nanchang 330006 People's Republic of China

2. Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou 510006 People's Republic of China

3. School of Pharmaceutical Sciences; Hainan Medical University; Haikou 571199 People's Republic of China

Funder

National Natural Science Foundation of China

Key Laboratory Foundation of Guangdong Province

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Toxicology,Molecular Biology,Molecular Medicine,Biochemistry,General Medicine

Reference33 articles.

1. Trantinterol, a Novel β2-Adrenoceptor Agonist, Noncompetitively Inhibits P-Glycoprotein Function in Vitro and in Vivo

2. Identification of Three Novel Natural Product Compounds that Activate PXR and CAR and Inhibit Inflammation

3. Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein

4. In Vitro P-glycoprotein Efflux Ratio Can Predict the In Vivo Brain Penetration Regardless of Biopharmaceutics Drug Disposition Classification System Class

5. Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells

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