Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells

Author:

Wang Li12,Wang Changyuan12,Jia Yongming12,Liu Zhihao12,Shu Xiaohong12,Liu Kexin12

Affiliation:

1. Department of Clinical Pharmacology, College of Pharmacy; Dalian Medical University; China

2. Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning; Dalian Medical University; China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference29 articles.

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3. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation;Brognard;Cancer Res,2001

4. Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway;Chen;Cancer Biol Ther,2015

5. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism;Chiarini;Leukemia,2008

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