Denitrative Hydroxylation of Unactivated Nitroarenes**

Author:

Duff Lee1,Meakin Harry1,Richardson Adam1,Greener Andrew J.1,Smith George W. A.1,Ocaña Ivan1,Chechik Victor1,James Michael J.2ORCID

Affiliation:

1. Department of Chemistry University of York Heslington York YO10 5DD UK

2. Department of Chemistry The University of Manchester Oxford Road Manchester M13 9PL UK

Abstract

AbstractA one‐step method for the conversion of nitroarenes into phenols under operationally simple, transition‐metal‐free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three‐step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron‐catalysed radical‐nucleophilic substitution (SRN1) chain mechanism.

Funder

Leverhulme Trust

Royal Society

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference113 articles.

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