Practical olefin hydroamination with nitroarenes

Author:

Gui Jinghan1,Pan Chung-Mao1,Jin Ying1,Qin Tian1,Lo Julian C.1,Lee Bryan J.1,Spergel Steven H.2,Mertzman Michael E.2,Pitts William J.2,La Cruz Thomas E.3,Schmidt Michael A.3,Darvatkar Nitin4,Natarajan Swaminathan R.4,Baran Phil S.1

Affiliation:

1. Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.

2. Discovery Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543, USA.

3. Chemical Development, Bristol-Myers Squibb, New Brunswick, NJ 08903, USA.

4. Kemxtree LLC, 1370 Hamilton Street, Somerset, NJ 08873, USA.

Abstract

Stitching C-N bonds from nitro groups Numerous compounds in pharmaceutical research have carbon-nitrogen bonds, and chemists are always looking for ways to make them more efficiently. Gui et al. present a method that links the carbon in an olefin to the nitrogen in a nitroaromatic compound (see the Perspective by Kürti). Nitroaromatics are readily available, and the method tolerates a wide range of other chemical groups present on either reacting partner. Science , this issue p. 886 ; see also p. 863

Funder

NSF

National Institute of General Medical Sciences

Bristol-Myers Squibb

China Scholarship Council

Pharmaron

Shanghai Institute of Organic Chemistry

Zhejiang Medicine Co.

Sigma-Aldrich

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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