Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols-Reference-Cited by-同舟云学术

Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols

Published:2024-07-20 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Xu Jia,Liu Yilin,Wang Qing,Tao Xiangzhang,Ni Shengyang,Zhang Weigang,Yu Lei,Pan Yi,Wang Yi^ORCID

Abstract

AbstractAlkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions. A range of primary, secondary, and tertiary alkylamines are obtained. This practical procedure can be scaled up through electrochemical continuous flow technique.

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-50596-3.pdf

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