Denitrative Sulfonylation of Nitroarenes with Sodium Sulfinates

Author:

Da Luz Jonathan1,Čierna Michaela1,Cooper Bradley D.1,Harris Thomas D.1,Lim Ethan R. X.1,Carney Jonathan R.2,James Michael J.1ORCID

Affiliation:

1. Department of Chemistry, The University of Manchester

2. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca

Abstract

AbstractA one-step method to convert nitroarenes into aryl sulfones under operationally simple, transition-metal-free conditions is described. A range of nitroarenes were reacted with sodium sulfinates and caesium carbonate in N,N′-dimethylpropyleneurea to afford aryl sulfones in up to 83% yield.

Funder

University of Manchester

Slovak Academic Information Agency

Slovenská technická univerzita v Bratislave

AstraZeneca

Publisher

Georg Thieme Verlag KG

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