Affiliation:
1. LIMA – UMR 7042 Université de Strasbourg, CNRS, Université de Haute-Alsace ECPM 25 rue Becquerel 67000 Strasbourg France
Abstract
AbstractThe fully regio‐ and stereoselective Zn‐catalyzed hydrocyanation of ynamides is reported and represents a general access to various trisubstituted E‐α‐enamidonitriles. The catalyst‐free photoisomerization selectively yields the energetically comparable Z‐stereoisomer. Finally, the synthetic potential of these new α‐enamidonitriles was evaluated through the synthesis of original heterocycles.
Subject
General Chemistry,Catalysis,Organic Chemistry