Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography

Author:

Konstantinidis Spyridon1,Titchener-Hooker Nigel1,Velayudhan Ajoy1

Affiliation:

1. The Advanced Centre for Biochemical Engineering; Department of Biochemical Engineering; University College London; London UK

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Reference19 articles.

1. Design of experiments applications in bioprocessing: Concepts and approach;Kumar;Biotechnol. Progr,2014

2. Bioprocess optimization using design-of-experiments methodology;Mandenius;Biotechnol. Progr,2008

3. A high throughput template for optimizing Drosophila organ culture with response surface methods;Zartman;Development,2013

4. Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies;Chollangi;Biotechnol. Progr.,2015

5. Development of an intermediate chromatography step in an insulin purification process. The use of a High Throughput Process Development approach based on selectivity parameters;Heldin;J. Chromatogr. B,2014

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