Hybrid optimization of preparative chromatography for a ternary monoclonal antibody mixture
Author:
Affiliation:
1. Department of Biochemical Engineering, The Advanced Centre for Biochemical EngineeringUniversity College London London UK
2. Biopharm Process ResearchBioPharm R&D, GlaxoSmithKine Stevenage UK
Funder
Engineering and Physical Sciences Research Council
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2849
Reference29 articles.
1. Domain antibody downstream process optimization: High-throughput strategy and analytical methods
2. High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody
3. Two-stage chromatographic separation of aggregates for monoclonal antibody therapeutics
4. Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates
5. PROCESS DEVELOPMENT FOR ROBUST REMOVAL OF AGGREGATES USING CATION EXCHANGE CHROMATOGRAPHY IN MONOCLONAL ANTIBODY PURIFICATION WITH IMPLEMENTATION OF QUALITY BY DESIGN
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1. A scoping review of supervised learning modelling and data-driven optimisation in monoclonal antibody process development;Digital Chemical Engineering;2023-06
2. Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics;Annual Review of Chemical and Biomolecular Engineering;2020-06-07
3. Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development;Frontiers in Bioengineering and Biotechnology;2019-12-20
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