Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis-Reference-Cited by-同舟云学术

Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

Published:2022-04-11 Issue:11 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Niu Shuaishuai¹²,Zhang Guoning²,Wang Na³⁴,Lv Guangyao¹,Liu Jinsong³⁴,Wang Hongbo¹⁵,Fang Wei‐Shuo²

Affiliation:

1. Key Laboratory of Molecular Pharmacology and Drug Evaluation Ministry of Education Collaborative Innovation Center of Advanced Drug Delivery Systems and Biotech Drugs in Universities of Shandong Yantai University Yantai 264005 China

2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

3. State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China

4. Guangdong Provincial Key Laboratory of Biocomputing Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China

5. Bohai Rim Advanced Research Institute for Drug Discovery Yantai 264005 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100778

Reference17 articles.

1. Nonsteroidal FXR Ligands: Current Status and Clinical Applications

2. Chemistry and Pharmacology of GPBAR1 and FXR Selective Agonists, Dual Agonists, and Antagonists

3. A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR

4. Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

5. Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor

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