A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR

Author:

Urizar Nancy L.1,Liverman Amy B.2,Dodds D'Nette T.1,Silva Frank Valentin1,Ordentlich Peter3,Yan Yingzhuo3,Gonzalez Frank J.4,Heyman Richard A.3,Mangelsdorf David J.2,Moore David D.1

Affiliation:

1. Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

2. Howard Hughes Medical Institute, University of Texas - Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

3. X-Ceptor Therapeutics, Inc., 4757 Nexus Center Drive, San Diego, CA 92121, USA.

4. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Building 37, Room 3E24, Bethesda, MD 20892, USA.

Abstract

Extracts of the resin of the guggul tree ( Commiphora mukul ) lower LDL (low-density lipoprotein) cholesterol levels in humans. The plant sterol guggulsterone [4,17(20)-pregnadiene-3,16-dione] is the active agent in this extract. We show that guggulsterone is a highly efficacious antagonist of the farnesoid X receptor (FXR), a nuclear hormone receptor that is activated by bile acids. Guggulsterone treatment decreases hepatic cholesterol in wild-type mice fed a high-cholesterol diet but is not effective in FXR-null mice. Thus, we propose that inhibition of FXR activation is the basis for the cholesterol-lowering activity of guggulsterone. Other natural products with specific biologic effects may modulate the activity of FXR or other relatively promiscuous nuclear hormone receptors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 458 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3