Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype**-Reference-Cited by-同舟云学术

Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype**

Published:2022-05-09 Issue:12 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Asquith Christopher R. M.¹²^ORCID,Temme Louisa¹^ORCID,East Michael P.²^ORCID,Laitinen Tuomo³^ORCID,Pickett Julie¹^ORCID,Kwarcinski Frank E.⁴,Sinha Parvathi⁴,Wells Carrow I.¹^ORCID,Johnson Gary L.²⁵,Zutshi Reena⁴^ORCID,Drewry David H.¹⁵^ORCID

Affiliation:

1. Structural Genomics Consortium UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

2. Department of Pharmacology School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

3. School of Pharmacy Faculty of Health Sciences University of Eastern Finland 70211 Kuopio Finland

4. Luceome Biotechnologies, LLC Tucson AZ 85719 USA

5. Lineberger Comprehensive Cancer Center School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Funder

Canada Foundation for Innovation

Innovative Medicines Initiative

National Institutes of Health

University of North Carolina at Chapel Hill

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200161

Reference60 articles.

1. Development of an intracellularly acting inhibitory peptide selective for PKN

2. Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

3. Differential Binding of RhoA, RhoB, and RhoC to Protein Kinase C-Related Kinase (PRK) Isoforms PRK1, PRK2, and PRK3: PRKs Have the Highest Affinity for RhoB

4. The Structure and Function of PKN, a Protein Kinase Having a Catalytic Domain Homologous to That of PKC

5. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase

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