GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor
Author:
Affiliation:
1. Graduate Entry Medical School and Materials and Surface Science Institute; University of Limerick; Limerick; Ireland
2. Laboratorio Farmaceutico CT; Sanremo; Italy
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/syn.21672/fullpdf
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1. GET73 modulates lipopolysaccharide- and ethanol-induced increase in cytokine/chemokine levels in primary cultures of microglia of rat cerebral cortex;Pharmacological Reports;2024-08-01
2. An inpatient human laboratory study assessing the safety and tolerability, pharmacokinetics, and biobehavioral effect of GET 73 when co-administered with alcohol in individuals with alcohol use disorder;Psychopharmacology;2021-11-03
3. In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5;Frontiers in Pharmacology;2018-04-05
4. Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans;Journal of Psychopharmacology;2018-01-23
5. A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers;European Journal of Pharmaceutical Sciences;2017-11
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