A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers-Reference-Cited by-同舟云学术

A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers

Published:2017-11 Issue: Volume:109 Page:78-85
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Haass-Koffler Carolina L.,Goodyear Kimberly,Long Victoria M.,Tran Harrison H.,Loche Antonella,Cacciaglia Roberto,Swift Robert M.,Leggio Lorenzo^ORCID

Funder

CT Laboratories

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference21 articles.

1. GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor;Beggiato;Synapse,2013

2. Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats;Besheer;Alcohol. Clin. Exp. Res.,2008

3. Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats;Colombo;Addict. Biol.,2006

4. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders;Conn;Nat. Rev. Drug Discov.,2009

5. Glutamate and GABA in appetite regulation;Delgado;Front. Endocrinol. (Lausanne),2013

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