Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors-Reference-Cited by-同舟云学术

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Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors

Published:2015-08-14 Issue:40 Volume:54 Page:11754-11759
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Smith Davis E.¹,Marquez Isaac¹,Lokensgard Melissa E.¹,Rheingold Arnold L.²,Hecht David A.³,Gustafson Jeffrey L.¹

Affiliation:

1. Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182‐1030 (USA)

2. Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093‐0385 (USA)

3. School of Mathematics, Science & Engineering, Southwestern College, 900 Otay Lakes Rd, Chula Vista, CA 91910 (USA)

Funder

SDSU startup

SDSU University Grants Program

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201506085

Reference42 articles.

1. The Protein Kinase Complement of the Human Genome

2. Protein kinases — the major drug targets of the twenty-first century?

3. Targeting cancer with small molecule kinase inhibitors

4. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations

5. Polypharmacology: Challenges and Opportunities in Drug Discovery

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