Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist-Reference-Cited by-同舟云学术

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Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist

Published:2024 Issue:7 Volume:15 Page:2357-2371
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Xu Zhou¹^ORCID,Wang Zhongyuan¹,Shi Xiaona¹^ORCID,Ding Rui¹^ORCID,Han Li²,Yang Xueping²,Zhang Hongmei²^ORCID,Hobson Adrian D.³^ORCID

Affiliation:

1. WuXi AppTec, Tianjin Economic-Technological Development Area TEDA, 168 Nanhai Road, TJS, 300457, China

2. WuXi AppTec, Waigaoqiao Free Trade Zone, 288 Fute Zhong Road, Pudong New Area, Shanghai, 200131, China

3. AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, USA

Abstract

A torsion angle scan of a virtual library predicts compounds that will afford stable atropisomers identified as potent non-steroidal glucocorticoid receptor modulators.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00245H

Reference18 articles.

1. A review of drug isomerism and its significance

2. THALIDOMIDE AND CONGENITAL ABNORMALITIES

3. THALIDOMIDE AND CONGENITAL ABNORMALITIES

4. The concept of chiral conformers and its significance in molecular pharmacology

5. A twist of nature – the significance of atropisomers in biological systems

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