Affiliation:
1. School of Chemistry Chair of Organic Chemistry Trinity Biomedical Sciences Institute Trinity College Dublin The University of Dublin 152–160 Pearse Street Dublin D02R590 Ireland
2. CQC, Coimbra Chemistry Centre University of Coimbra Coimbra 3004-535 Portugal
3. Institute for Advanced Study (TUM-IAS) Focus Group–Molecular and Interfacial Engineering of Organic Nanosystems Technical University of Munich Lichtenberg Str. 2a 85748 Garching Germany
Abstract
AbstractPorphyrin atropisomerism, which arises from restricted σ‐bond rotation between the macrocycle and a sufficiently bulky substituent, was identified in 1969 by Gottwald and Ullman in 5,10,15,20‐tetrakis(o‐hydroxyphenyl)porphyrins. Henceforth, an entirely new field has emerged utilizing this transformative tool. This review strives to explain the consequences of atropisomerism in porphyrins, the methods which have been developed for their separation and analysis and present the diverse array of applications. Porphyrins alone possess intriguing properties and a structure which can be easily decorated and molded for a specific function. Therefore, atropisomerism serves as a transformative tool, making it possible to obtain even a specific molecular shape. Atropisomerism has been thoroughly exploited in catalysis and molecular recognition yet presents both challenges and opportunities in medicinal chemistry.
Funder
Irish Research Council
HORIZON EUROPE Marie Sklodowska-Curie Actions
Science Foundation Ireland