Structure‐Based Design of a Macrocyclic PROTAC-Reference-Cited by-同舟云学术

Structure‐Based Design of a Macrocyclic PROTAC

Published:2019-12-12 Issue:4 Volume:59 Page:1727-1734
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Testa Andrea¹^ORCID,Hughes Scott J.¹^ORCID,Lucas Xavier¹²^ORCID,Wright Jane E.¹,Ciulli Alessio¹^ORCID

Affiliation:

1. Division of Biological Chemistry and Drug Discovery School of Life Sciences University of Dundee Dow Street Dundee DD1 5EH Scotland UK

2. Current address: Roche Pharma Research and Early Development Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 CH-4070 Basel Switzerland

Funder

European Research Council

H2020 Marie Skłodowska-Curie Actions

Wellcome Trust

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201914396

Reference33 articles.

1. Targeted Protein Degradation: from Chemical Biology to Drug Discovery

2. A critical evaluation of the approaches to targeted protein degradation for drug discovery

3. Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

4. Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

5. PROteolysis TArgeting Chimeras (PROTACs) — Past, present and future

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